ABSTRACT
Paraneoplastic cerebellar degeneration (PCD), the one of rare paraneoplastic syndromes, refer to clinical disorders associated mostly with lung, ovarian and breast cancer, but not directly caused by cancer or its metastasis. PCD is a condition whereby the Purkinje cells of the cerebellar cortex are damaged secondary to an autoimmune process. We report here on the case of PCD of subacute onset in a patient at 7 months after surgery for ovarian cancer. Although the cases of PCD has rarely been reported, the present case appears to be the first in Korea in which PCD was associated with anti-Yo antibody in patient with chemotherapy-responsive ovarian cancer. The clinical significance of PCD associated with anti-Yo antibody is reviewed.
Subject(s)
Humans , Breast Neoplasms , Cerebellar Cortex , Korea , Lung , Neoplasm Metastasis , Ovarian Neoplasms , Paraneoplastic Cerebellar Degeneration , Paraneoplastic Syndromes , Purkinje CellsABSTRACT
A patient with small cell lung cancer presented with a rare presentation of an acute onset pancerebellar dysfunction. His clinical condition markedly improved following the surgical removal of the tumor and chemo- and radiotherapy.
Subject(s)
Carcinoma, Small Cell/complications , Combined Modality Therapy , Humans , Lung Neoplasms/complications , Male , Middle Aged , Paraneoplastic Cerebellar Degeneration/etiology , Radiography, Thoracic , ThoracotomyABSTRACT
Descrevemos caso de uma paciente de 40 anos com quadro de degeneraçao cerebelar subaguda paraneoplásica associada a tumor ovariano. Apresentamos breve revisao sobre as manifestaçoes clínicas e laboratoriais desta síndrome, enfatizando a importância do seu reconhecimento, o que possibilita muitas vezes a detecçao e tratamento precoce da doença primária